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Article

Achieving large dynamic range control of gene expression with a compact RNA transcription-translation regulator.

Nucleic acids research - 19 May 2017

Westbrook Alexandra M, Lucks Julius B

Abstract excerpt

RNA transcriptional regulators are emerging as versatile components for genetic network construction. However, these regulators suffer from incomplete repression in their OFF state, making their dynamic range less than that of their protein counterparts. This incomplete repression causes expression leak, which impedes the construction of larger synthetic regulatory networks as leak propagation can interfere with...

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Identifiers

PMID: 28387839
DOI: 10.1093/nar/gkx215
PMCID: PMC5435934

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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