Article
Ergosterol content specifies targeting of tail-anchored proteins to mitochondrial outer membranes.
Molecular biology of the cell - 1 Oct 2012
Krumpe Katrin, Frumkin Idan, Herzig Yonatan, Rimon Nitzan, Özbalci Cagakan, Brügger Britta, Rapaport Doron, Schuldiner Maya
Abstract excerpt
Tail-anchored (TA) proteins have a single C-terminal transmembrane domain, making their biogenesis dependent on posttranslational translocation. Despite their importance, no dedicated insertion machinery has been uncovered for mitochondrial outer membrane (MOM) TA proteins. To decipher the molecular mechanisms guiding MOM TA protein insertion, we performed two independent systematic microscopic screens in which...
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