Article
Evolution of mitochondrial oxa proteins from bacterial YidC. Inherited and acquired functions of a conserved protein insertion machinery.
The Journal of biological chemistry - 1 Apr 2005
Preuss Marc, Ott Martin, Funes Soledad, Luirink Joen, Herrmann Johannes M
Abstract excerpt
Members of the Oxa1/YidC family are involved in the biogenesis of membrane proteins. In bacteria, YidC catalyzes the insertion and assembly of proteins of the inner membrane. Mitochondria of animals, fungi, and plants harbor two distant homologues of YidC, Oxa1 and Cox18/Oxa2. Oxa1 plays a pivotal role in the integration of mitochondrial translation products into the inner membrane of mitochondria. It contains a...
Topics
- Cross-Linking Reagents
- Dose-Response Relationship, Drug
- Escherichia coli
- Escherichia coli Proteins
- Evolution, Molecular
- Gene Deletion
- Genetic Complementation Test
- Immunoprecipitation
- Macromolecular Substances
- Membrane Proteins
- Membrane Transport Proteins
- Mitochondria