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Article

Translocation and assembly of mitochondrially coded Saccharomyces cerevisiae cytochrome c oxidase subunit Cox2 by Oxa1 and Yme1 in the absence of Cox18.

Genetics - 1 Jun 2009

Fiumera Heather L, Dunham Maitreya J, Saracco Scott A, Butler Christine A, Kelly Jessica A, Fox Thomas D

Abstract excerpt

Members of the Oxa1/YidC/Alb3 family of protein translocases are essential for assembly of energy-transducing membrane complexes. In Saccharomyces cerevisiae, Oxa1 and its paralog, Cox18, are required for assembly of Cox2, a mitochondrially encoded subunit of cytochrome c oxidase. Oxa1 is known to be required for cotranslational export of the Cox2 N-terminal domain across the inner mitochondrial membrane, while...

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Identifiers

PMID: 19307606
DOI: 10.1534/genetics.109.101196
PMCID: PMC2691760

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