Pkd1 Mutation Has No Apparent Effects on Peroxisome Structure or Lipid Metabolism.

Abstract excerpt

Background: Multiple studies of tissue and cell samples from patients and preclinical models of autosomal dominant polycystic kidney disease report abnormal mitochondrial function and morphology and suggest metabolic reprogramming is an intrinsic feature of this disease. Peroxisomes interact with mitochondria physically and functionally, and congenital peroxisome biogenesis disorders can cause various phenotypes,...

Topics

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• Lipid Metabolism
• Mice
• Mutation
• Peroxisomes
• Polycystic Kidney, Autosomal Dominant