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Article

Cardiac dysfunction and peri-weaning mortality in malonyl-coenzyme A decarboxylase (MCD) knockout mice as a consequence of restricting substrate plasticity.

Journal of molecular and cellular cardiology - 1 Oct 2014

Aksentijević Dunja, McAndrew Debra J, Karlstädt Anja, Zervou Sevasti, Sebag-Montefiore Liam, Cross Rebecca, Douglas Gillian, Regitz-Zagrosek Vera, Lopaschuk Gary D, Neubauer Stefan, Lygate Craig A

Abstract excerpt

UNLABELLED: Inhibition of malonyl-coenzyme A decarboxylase (MCD) shifts metabolism from fatty acid towards glucose oxidation, which has therapeutic potential for obesity and myocardial ischemic injury. However, ~40% of patients with MCD deficiency are diagnosed with cardiomyopathy during infancy. AIM: To clarify the link between MCD deficiency and cardiac dysfunction in early life and to determine the...

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Identifiers

PMID: 25066696
DOI: 10.1016/j.yjmcc.2014.07.008
PMCID: PMC4169183

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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