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Article

Zebrafish Model of Severe Combined Immunodeficiency (SCID) Due to JAK3 Mutation.

Biomolecules - 20 Oct 2022

Basheer Faiza, Lee Effie, Liongue Clifford, Ward Alister C

Abstract excerpt

JAK3 is principally activated by members of the interleukin-2 receptor family and plays an essential role in lymphoid development, with inactivating JAK3 mutations causing autosomal-recessive severe combined immunodeficiency (SCID). This study aimed to generate an equivalent zebrafish model of SCID and to characterize the model across the life-course. Genome editing of zebrafish jak3 created mutants similar to...

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Identifiers

PMID: 36291730
DOI: 10.3390/biom12101521
PMCID: PMC9599616

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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