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Article

Differences between immunodeficient mice generated by classical gene targeting and CRISPR/Cas9-mediated gene knockout.

Transgenic research - 1 Jun 2018

Lee Jae Hoon, Park Jong-Hyung, Nam Tae-Wook, Seo Sun-Min, Kim Jun-Young, Lee Han-Kyul, Han Jong Hyun, Park Song Yi, Choi Yang-Kyu, Lee Han-Woong

Abstract excerpt

Immunodeficient mice are widely used for pre-clinical studies to understand various human diseases. Here, we report the generation of four immunodeficient mouse models using CRISPR/Cas9 system without inserting any foreign gene sequences such as NeoR cassettes and their characterization. By eliminating any possible effects of adding a NeoR cassette, our mouse models may allow us to better elucidate the in vivo...

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Identifiers

PMID: 29594927
DOI: 10.1007/s11248-018-0069-y
PMCID: PMC5986857

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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