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A CRISPR-Cas9 delivery system for in vivo screening of genes in the immune system

10 Apr 2019

Abstract excerpt

Abstract Therapies that target the function of immune cells have significant clinical efficacy in diseases such as cancer and autoimmunity. Although functional genomics has accelerated therapeutic target discovery in cancer, its use in primary immune cells is limited because vector delivery is inefficient and can perturb cell states. Here we describe CHIME: CHimeric IMmune Editing, a CRISPR-Cas9 bone marrow...

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PMID: 30971695
DOI: 10.1038/s41467-019-09656-2

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