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Article

Interpreting coronary artery disease GWAS results: A functional genomics approach assessing biological significance.

PloS one - 1 Jan 2022

Hartmann Katherine, Seweryn Michał, Sadee Wolfgang

Abstract excerpt

Genome-wide association studies (GWAS) have implicated 58 loci in coronary artery disease (CAD). However, the biological basis for these associations, the relevant genes, and causative variants often remain uncertain. Since the vast majority of GWAS loci reside outside coding regions, most exert regulatory functions. Here we explore the complexity of each of these loci, using tissue specific RNA sequencing data...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35192625
DOI: 10.1371/journal.pone.0244904
PMCID: PMC8863290

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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