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Identification of binding sites for the group A streptococcal global regulator CovR

1 Mar 2002

Abstract excerpt

The CovRS two-component system (also called CsrRS) of the group A streptococcus (GAS) acts as a global regulator, influencing the transcription of at least six virulence factors. The synthesis of the hyaluronic acid capsule, a virulence factor encoded by the hasABC operon, is negatively regulated by CovRS. We confirmed that phosphorylation of CovR increases its binding to a DNA fragment containing the hasA...

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PMID: 11918804
DOI: 10.1046/j.1365-2958.2002.02810.x

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