Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Distinct single amino acid replacements in the control of virulence regulator protein differentially impact streptococcal pathogenesis.

PLoS pathogens - 1 Oct 2011

Horstmann Nicola, Sahasrabhojane Pranoti, Suber Bryce, Kumaraswami Muthiah, Olsen Randall J, Flores Anthony, Musser James M, Brennan Richard G, Shelburne Samuel A

Abstract excerpt

Sequencing of invasive strains of group A streptococci (GAS) has revealed a diverse array of single nucleotide polymorphisms in the gene encoding the control of virulence regulator (CovR) protein. However, there is limited information regarding the molecular mechanisms by which CovR single amino acid replacements impact GAS pathogenesis. The crystal structure of the CovR C-terminal DNA-binding domain was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acids
Share to Longevity

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutagenesis, Site-Directed

Share to Protein Structure, Secondary

Share to Repressor Proteins

Share to RNA, Bacterial

Share to Streptococcal Infections

Share to Streptococcus pyogenes

Source

Open in PubMed Open full text

Identifiers

PMID: 22028655
DOI: 10.1371/journal.ppat.1002311
PMCID: PMC3197619

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Distinct single amino acid replacements in the control of virulence regulator protein differentially impact streptococcal pathogenesis.PMID 22028655Read ↗

Genome-Wide Analysis of Group A Streptococci Reveals a Mutation That Modulates Global Phenotype and Disease SpecificitySemantic proximity Read ↗

Virulence control in group A Streptococcus by a two-component gene regulatory system: global expression profiling and in vivo infection modeling.Semantic proximity Read ↗

CovS inactivation reduces CovR promoter binding at diverse virulence factor encoding genes in group A StreptococcusSemantic proximity Read ↗

The CovR regulatory network drives the evolution of Group B <i>Streptococcus</i> virulenceSemantic proximity Read ↗

Whole-Genome Comparison Uncovers Genomic Mutations between Group B Streptococci Sampled from Infected Newborns and Their Mothers.Semantic proximity Read ↗

The two faces of Janus: virulence gene regulation by CovR/S in group A streptococciSemantic proximity Read ↗

Characterization of a novel covS SNP identified in Australian group A Streptococcus isolates derived from the M1UK lineage.Semantic proximity Read ↗

CovS Simultaneously Activates and Inhibits the CovR-Mediated Repression of Distinct Subsets of Group A <i>Streptococcus</i> Virulence Factor-Encoding GenesSemantic proximity Read ↗

The CovR regulatory network drives the evolution of Group B Streptococcus virulenceSemantic proximity Read ↗

Naturally occurring single amino acid replacements in a regulatory protein alter streptococcal gene expression and virulence in mice.Semantic proximity Read ↗

Single Amino Acid Replacements in RocA Disrupt Protein-Protein Interactions To Alter the Molecular Pathogenesis of Group A Streptococcus.Semantic proximity Read ↗

Cellular interactions of covR/S mutant group A Streptococci.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.