Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Liver Zonation in Health and Disease: Hypoxia and Hypoxia-Inducible Transcription Factors as Concert Masters

11 May 2019

Abstract excerpt

The liver and its zonation contribute to whole body homeostasis. Acute and chronic, not always liver, diseases impair proper metabolic zonation. Various underlying pathways, such as β-catenin, hedgehog signaling, and the Hippo pathway, along with the physiologically occurring oxygen gradient, appear to be contributors. Interestingly, hypoxia and hypoxia-inducible transcription factors can orchestrate those...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer, Hypoxia, and Metabolism
Share to Liver Disease Diagnosis and Treatment
Share to Liver physiology and pathology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31083568
DOI: 10.3390/ijms20092347

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Liver Zonation in Health and Disease: Hypoxia and Hypoxia-Inducible Transcription Factors as Concert MastersPMID 31083568Read ↗

Pre-clinical and clinical investigations of metabolic zonation in liver diseases: The potential of microphysiology systemsSemantic proximity Read ↗

The Hippo Pathway in Liver Homeostasis and PathophysiologySemantic proximity Read ↗

Liver zonation, revisitedSemantic proximity Read ↗

The Canonical Wnt Pathway as a Key Regulator in Liver Development, Differentiation and Homeostatic RenewalSemantic proximity Read ↗

Hepatic Zonation in MASLD: Old Question, New Challenge in the Era of Spatial OmicsSemantic proximity Read ↗

Organ patterning in the adult stage: The role of Wnt/β‐catenin signaling in liver zonation and beyondSemantic proximity Read ↗

The origin and molecular evolution of the mammalian liver cell architectureSemantic proximity Read ↗

A spatial transcriptomics atlas of live donors reveals unique zonation patterns in the healthy human liverSemantic proximity Read ↗

In Search of Zonation Markers to Identify Liver Functional DisordersSemantic proximity Read ↗

Liver fibrogenesis: un update on established and emerging basic conceptsSemantic proximity Read ↗

RISING STARS: Liver sinusoidal endothelial transcription factors in metabolic homeostasis and diseaseSemantic proximity Read ↗

Compartmentalization, cooperation, and communication: The 3Cs of Hepatocyte zonationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.