Article

Spatial transcriptomics of healthy and fibrotic human liver at single-cell resolution

2024-02-07

Abstract excerpt

Single-cell RNA sequencing (scRNA-seq) has advanced our understanding of cell types and their heterogeneity within the human liver, but the spatial organization at single-cell resolution has not yet been described. Here we apply multiplexed error robust fluorescent in situ hybridization (MERFISH) to map the zonal distribution of hepatocytes, resolve subsets of macrophage and mesenchymal populations, and investigat...

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Literature Corpus work: 2761a895-95e4-5339-b8b5-55b530d20e1e
DOI: 10.1101/2024.02.02.578633

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