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Article

Structural basis for degenerate recognition of natural HIV peptide variants by cytotoxic lymphocytes.

The Journal of biological chemistry - 21 Jul 2006

Martinez-Hackert Erik, Anikeeva Nadia, Kalams Spyros A, Walker Bruce D, Hendrickson Wayne A, Sykulev Yuri

Abstract excerpt

It is well established that even small changes in amino acid side chains of antigenic peptide bound to major histocompatibility complex (MHC) protein may completely abrogate recognition of the peptide-MHC (pMHC) complex by the T cell receptor (TCR). Often, however, several nonconservative substitutions in the peptide antigen are accommodated and do not impair its recognition by TCR. For example, a preponderance...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to HLA-A2 Antigen

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Source

Identifiers

PMID: 16702212
DOI: 10.1074/jbc.M601934200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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