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Article

Germ Line-governed Recognition of a Cancer Epitope by an Immunodominant Human T-cell Receptor

16 Jul 2009

Abstract excerpt

CD8(+) T-cells specific for MART-1-(26-35), a dominant melanoma epitope restricted by human leukocyte antigen (HLA)-A*0201, are exceptionally common in the naive T-cell repertoire. Remarkably, the TRAV12-2 gene is used to encode the T-cell receptor alpha (TCRalpha) chain in >87% of these T-cells. Here, the molecular basis for this genetic bias is revealed from the structural and thermodynamic properties of an...

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PMID: 19605354
DOI: 10.1074/jbc.m109.022509

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