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Article

Interactions between nuclear and mitochondrial SNPs and Parkinson's disease risk.

Mitochondrion - 1 Mar 2022

Pickett Sarah J, Deen Dasha, Pyle Angela, Santibanez-Koref Mauro, Hudson Gavin

Abstract excerpt

Interactions between the products of the nuclear and mitochondrial genomes are critical for the function of most eukaryotic cells. Recently the introduction of mitochondrial replacement therapy has raised the question of incompatibilities between mitochondrial and nuclear variants, and their potential influence on the genetic makeup of human populations. Such interactions could also contribute to the variability...

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Identifiers

PMID: 35167983
DOI: 10.1016/j.mito.2022.02.002
PMCID: PMC7617118

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