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Article

Mitonuclear interactions influence Alzheimer's disease risk.

Neurobiology of aging - 1 Mar 2020

Andrews Shea J, Fulton-Howard Brian, Patterson Christopher, McFall G Peggy, Gross Alden, Michaelis Elias K, Goate Alison, Swerdlow Russell H, Pa Judy

Abstract excerpt

We examined the associations between mitochondrial DNA haplogroups (MT-hgs; mitochondrial haplotype groups defined by a specific combination of single nucleotide polymorphisms labeled as letters running from A to Z) and their interactions with a polygenic risk score composed of nuclear-encoded mitochondrial genes (nMT-PRS) with risk of dementia and age of onset (AOO) of dementia. MT-hg K (Odds ratio [OR]: 2.03...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 31784277
DOI: 10.1016/j.neurobiolaging.2019.09.007
PMCID: PMC7205324

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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