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Article

Human brain mitochondrial-nuclear cross-talk is cell-type specific and is perturbed by neurodegeneration

2021-02-05

Abstract excerpt

Mitochondrial dysfunction contributes to the pathogenesis of many neurodegenerative diseases as mitochondria are essential to neuronal function. The mitochondrial genome encodes a small number of core respiratory chain proteins, whereas the vast majority of mitochondrial proteins are encoded by the nuclear genome. Here we focus on establishing a profile of nuclear-mitochondrial transcriptional relationships in hea...

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Literature Corpus work
d6fb1ccb-67af-5de3-8fdb-c7dbb37b9ccb
DOI
10.1101/2021.02.04.429781
Open publication

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Human brain mitochondrial-nuclear cross-talk is cell-type specific and is perturbed by neurodegenerationDOI 10.1101/2021.02.04.429781
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