Article
Mitonuclear interactions influence Alzheimer’s disease risk
2019-05-31
Abstract excerpt
We examined the associations between mitochondrial DNA haplogroups (MT-hg) and their interactions with a polygenic risk score based on nuclear-encoded mitochondrial genes (nMT-PRS) with risk of dementia and age of onset of dementia (AOO). Logistic regression was used to determine the effect of MT-hgs and nMT-PRS on dementia at baseline (332 controls / 204 cases). Cox proportional hazards models were used to model...
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Identifiers and source
- Literature Corpus work
- c0a85101-1785-5a8b-8ef1-156b0548c8cb
- DOI
- 10.1101/654400