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Nuclear Genes Associated with Mitochondrial DNA Processes as Contributors to Parkinson's Disease Risk

29 Jan 2021

Abstract excerpt

Over the past four decades, mitochondrial dysfunction has been a recurring theme in Parkinson's disease (PD) and is hypothesized to play a central role in its disease pathogenesis. Given the instrumental role of mitochondria in cellular energy production, their dysfunction can be detrimental to highly energy-dependent dopaminergic neurons, known to degenerate in PD. Mitochondria harbor multiple copies of their...

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PMID: 33513296
DOI: 10.1002/mds.28475

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