Article
Mitochondrial polymorphisms significantly reduce the risk of Parkinson disease.
American journal of human genetics - 1 Apr 2003
van der Walt Joelle M, Nicodemus Kristin K, Martin Eden R, Scott William K, Nance Martha A, Watts Ray L, Hubble Jean P, Haines Jonathan L, Koller William C, Lyons Kelly, Pahwa Rajesh, Stern Matthew B, Colcher Amy, Hiner Bradley C, Jankovic Joseph, Ondo William G, Allen Fred H, Goetz Christopher G, Small Gary W, Mastaglia Frank, Stajich Jeffrey M, McLaurin Adam C, Middleton Lefkos T, Scott Burton L, Schmechel Donald E, Pericak-Vance Margaret A, Vance Jeffery M
Abstract excerpt
Mitochondrial (mt) impairment, particularly within complex I of the electron transport system, has been implicated in the pathogenesis of Parkinson disease (PD). More than half of mitochondrially encoded polypeptides form part of the reduced nicotinamide adenine dinucleotide dehydrogenase (NADH)...
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