Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Myeloid cell genome-wide screen identifies variants associated with Mycobacterium tuberculosis-induced cytokine transcriptional responses.

The Journal of clinical investigation - 15 Jul 2025

Ivie Joshua J, Dill-McFarland Kimberly A, Simmons Jason D, Peterson Glenna J, Benchek Penelope H, Mayanja-Kizza Harriet, Veith Lily E, Agata Moeko, Ha Dang Tm, Nghia Ho Dt, Boom W Henry, Stein Catherine M, Khor Chiea C, Thwaites Guy E, Hai Hoang T, Thuong Nguyen Tt, Chang Xuling, Dunstan Sarah J, Hawn Thomas R

Abstract excerpt

Immune and clinical outcomes to Mycobacterium tuberculosis (Mtb) infection vary greatly between individuals, yet the underlying genetic and cellular mechanisms driving this heterogeneity remain poorly understood. We performed a cellular genome-wide association study to identify genetic variants associated with Mtb-induced monocyte transcriptional expression of IL1B, IL6, TNF, and IFNB1 via RNA-Seq in a Ugandan...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cohort Studies
Share to Cytokines

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome-Wide Association Study

Share to Mycobacterium tuberculosis

Share to Myeloid Cells

Share to Transcription, Genetic

Share to Tuberculosis

Share to Uganda

Source

Open in PubMed Open full text

Identifiers

PMID: 40402573
DOI: 10.1172/JCI179822
PMCID: PMC12259255

Genes

SLIT3
SLC1A1
TNF
IFNB1
IL1B
IL6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Myeloid cell genome-wide screen identifies variants associated with Mycobacterium tuberculosis-induced cytokine transcriptional responses.PMID 40402573Read ↗

Mycobacterium tuberculosis-dependent monocyte expression quantitative trait loci, cytokine production, and TB pathogenesisSemantic proximity Read ↗

<i>Mycobacterium tuberculosis</i>-dependent Monocyte Expression Quantitative Trait Loci and Tuberculosis PathogenesisSemantic proximity Read ↗

A functional genomics approach in Tanzanian population identifies distinct genetic regulators of cytokine production compared to European population.Semantic proximity Read ↗

Transcriptional Profiling of Human Peripheral Blood Mononuclear Cells Identifies Diagnostic Biomarkers That Distinguish Active and Latent TuberculosisSemantic proximity Read ↗

Identification of tuberculosis susceptibility genes with human macrophage gene expression profiles.Semantic proximity Read ↗

Whole blood transcriptional profiles and the pathogenesis of tuberculous meningitisSemantic proximity Read ↗

Genetic control of the transcriptional response to active tuberculosis disease and treatmentSemantic proximity Read ↗

Major Contribution of Myeloid Cells In TB specific Host Gene Signature: Revelations from Re-Analysis of Publicly Available DatasetsSemantic proximity Read ↗

Single-cell transcriptome sequencing reveals altered peripheral blood immune cells in patients with severe tuberculosisSemantic proximity Read ↗

Monocyte transcriptome signatures of inflammation and enhanced neutrophil recruitment characterize immunopathology in the blood of tuberculosis patientsSemantic proximity Read ↗

Immunopathogenic overlap between COVID-19 and tuberculosis identified from transcriptomic meta-analysis and human macrophage infectionSemantic proximity Read ↗

Human Alveolar and Monocyte-derived Human Macrophage Responses to Mycobacterium tuberculosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.