Article
Why are the phenotypes of TRAF6 knock-in and TRAF6 knock-out mice so different?
PloS one - 1 Jan 2022
Petrova Tsvetana, Bennett Kyle, Nanda Sambit, Strickson Sam, Scudamore Cheryl L, Prescott Alan R, Cohen Philip
Abstract excerpt
The expression of TNF-Receptor Associated Factor 6 (TRAF6) is essential for many physiological processes. Here we studied the phenotype of TRAF6[L74H] knock-in mice which are devoid of TRAF6 E3 ligase activity in every cell of the body, but express normal levels of the TRAF6 protein. Remarkably, TRAF6[L74H] mice have none of the phenotypes seen in TRAF6 KO mice. Instead TRAF6[L74H] mice display an entirely...
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