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Article

TRAF6-deficient mice display hypohidrotic ectodermal dysplasia.

Proceedings of the National Academy of Sciences of the United States of America - 25 Jun 2002

Naito Asuka, Yoshida Hisahiro, Nishioka Eri, Satoh Mizuho, Azuma Sakura, Yamamoto Tadashi, Nishikawa Shin-ichi, Inoue Jun-ichiro

Abstract excerpt

Tumor necrosis factor receptor (TNFR)-associated factor 6 (TRAF6) is an adapter protein that links signals from members of the TNFR superfamily and Toll/IL-1 receptor family to activation of transcription factors NFkappaB and AP-1. Analysis of TRAF6-deficient mice revealed that TRAF6 is essential for normal bone formation and establishment of immune and inflammatory systems. Here we report that TRAF6 deficiency...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 12060722
DOI: 10.1073/pnas.132636999
PMCID: PMC124373

Genes

TRAF6
EDAR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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