Article
TRAF6 is essential for maintenance of regulatory T cells that suppress Th2 type autoimmunity.
PloS one - 1 Jan 2013
Muto Go, Kotani Hitoshi, Kondo Taisuke, Morita Rimpei, Tsuruta Sanae, Kobayashi Takashi, Luche Hervé, Fehling Hans Joerg, Walsh Matthew, Choi Yongwon, Yoshimura Akihiko
Abstract excerpt
Regulatory T cells (Tregs) maintain immune homeostasis by limiting inflammatory responses. TRAF6 plays a key role in the regulation of innate and adaptive immunity by mediating signals from various receptors including the T-cell receptor (TCR). T cell-specific deletion of TRAF6 has been shown to induce multiorgan inflammatory disease, but the role of TRAF6 in Tregs remains to be investigated. Here, we generated...
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