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Article

TRAF2 deficiency results in hyperactivity of certain TNFR1 signals and impairment of CD40-mediated responses.

Immunity - 1 Sept 1999

Nguyen L T, Duncan G S, Mirtsos C, Ng M, Speiser D E, Shahinian A, Marino M W, Mak T W, Ohashi P S, Yeh W C

Abstract excerpt

Tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) can interact with various members of the TNF receptor family. Previously, we reported that TRAF2-deficient mice die prematurely and have elevated serum TNF levels. In this study, we demonstrate that TRAF2-deficient macrophages produce increased amounts of nitric oxide (NO) and TNF in response to TNF stimulation. Furthermore, we could enhance the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10514016
DOI: 10.1016/s1074-7613(00)80113-2

Genes

TRAF2
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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TRAF2 deficiency results in hyperactivity of certain TNFR1 signals and impairment of CD40-mediated responses.PMID 10514016Read ↗

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