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Article

TRAF6 negatively regulates TNFalpha-induced NF-kappaB activation.

Cytokine - 1 Feb 2009

Funakoshi-Tago Megumi, Kamada Noriyuki, Shimizu Taeko, Hashiguchi Yusuke, Tago Kenji, Sonoda Yoshiko, Kasahara Tadashi

Abstract excerpt

TNF receptor-associated factor 6 (TRAF6) is an essential adaptor protein for the Interleukin-1 (IL-1) signaling pathway; however, its role in the signaling of another proinflammatory cytokine, tumor necrosis factor alpha (TNFalpha, has not been explored. Interestingly, we observed that TNFalpha-induced expression of IL-6, CXCL1 and granulocyte macrophage colony stimulating factor (GM-CSF) were significantly...

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Source

Identifiers

PMID: 19091594
DOI: 10.1016/j.cyto.2008.10.010

Genes

TRAF6
CXCL1
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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