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Article

Transient response of serpinA3 during cellular stress.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Mar 2022

Sánchez-Navarro Andrea, Murillo-de-Ozores Adrián Rafael, Pérez-Villalva Rosalba, Linares Nadyeli, Carbajal-Contreras Héctor, Flores María Elena, Gamba Gerardo, Castañeda-Bueno María, Bobadilla Norma A

Abstract excerpt

We demonstrated that serpinA3c/k relocates from the cytoplasm to the apical tubular membrane (ATM) in chronic kidney disease (CKD), suggesting its secretion in luminal space in pathophysiological contexts. Here, we studied serpinA3c/k expression and secretion under different stressful conditions in vitro and in vivo. HEK-293 cells were transfected with a FLAG-tagged serpinA3c/k clone and exposed to H2 O2 or...

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PMID: 35147994
DOI: 10.1096/fj.202101912R

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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