Article
Glycosylation regulates the function and membrane localization of KCC4.
Biochimica et biophysica acta - 1 May 2013
Weng Tzu-Yu, Chiu Wen-Tai, Liu Hsiao-Sheng, Cheng Hung-Chi, Shen Meng-Ru, Mount David B, Chou Cheng-Yang
Abstract excerpt
Glycosylation plays a role in regulating many biological activities, including protein folding and cell surface expression of biomolecules. However, the importance of glycosylation for KCC4 function has not previously been demonstrated. Site-directed mutagenesis was performed on the four putative extracellular N-linked glycosylation sites of KCC4 to determine the role of these sites in KCC4 half-life, cell...
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