Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Elevated urinary CRELD2 is associated with endoplasmic reticulum stress-mediated kidney disease.

JCI insight - 7 Dec 2017

Kim Yeawon, Park Sun-Ji, Manson Scott R, Molina Carlos Af, Kidd Kendrah, Thiessen-Philbrook Heather, Perry Rebecca J, Liapis Helen, Kmoch Stanislav, Parikh Chirag R, Bleyer Anthony J, Chen Ying Maggie

Abstract excerpt

ER stress has emerged as a signaling platform underlying the pathogenesis of various kidney diseases. Thus, there is an urgent need to develop ER stress biomarkers in the incipient stages of ER stress-mediated kidney disease, when a kidney biopsy is not yet clinically indicated, for early therapeutic intervention. Cysteine-rich with EGF-like domains 2 (CRELD2) is a newly identified protein that is induced and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Kidney Injury
Share to Cardiac Surgical Procedures

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endoplasmic Reticulum Stress

Share to Nephritis, Interstitial

Share to Nephrotic Syndrome

Share to Podocytes

Share to Postoperative Complications

Share to Uromodulin

Source

Open in PubMed Open full text

Identifiers

PMID: 29212948
DOI: 10.1172/jci.insight.92896
PMCID: PMC5752286

Genes

CRELD2
EGF
UMOD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Elevated urinary CRELD2 is associated with endoplasmic reticulum stress-mediated kidney disease.PMID 29212948Read ↗

ERMP1 as a newly identified endoplasmic reticulum stress gatekeeper in chronic kidney diseaseSemantic proximity Read ↗

Endoplasmic reticulum stress and monogenic kidney diseases in precision nephrology.Semantic proximity Read ↗

Uromodulin-related autosomal-dominant tubulointerstitial kidney disease—pathogenetic insights based on a caseSemantic proximity Read ↗

Genome-wide mRNA profiling in urinary extracellular vesicles reveals stress gene signature for diabetic kidney diseaseSemantic proximity Read ↗

Disrupted uromodulin trafficking is rescued by targeting TMED cargo receptors.Semantic proximity Read ↗

Genomic and Proteomic Characterization of Acute Kidney InjurySemantic proximity Read ↗

Urinary exosomes as promising biomarkers for early kidney disease detectionSemantic proximity Read ↗

A comprehensive urine proteome database generated from patients with various renal conditions and prostate cancerSemantic proximity Read ↗

Diagnosis and Emerging Biomarkers of Cystic Fibrosis-Related Kidney Disease (CFKD)Semantic proximity Read ↗

Urine Glycoprotein Profile Reveals Novel Markers for Chronic Kidney DiseaseSemantic proximity Read ↗

Early involvement of cellular stress and inflammatory signals in the pathogenesis of tubulointerstitial kidney disease due to UMOD mutations.Semantic proximity Read ↗

Urine extracellular vesicles capture kidney transcriptome and hyperglycemia linked mRNA signatures for type 1 diabetic kidney diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.