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Article

Evidence for Activation of the Unfolded Protein Response in Collagen IV Nephropathies

21 Nov 2013

Abstract excerpt

Thin-basement-membrane nephropathy (TBMN) and Alport syndrome (AS) are progressive collagen IV nephropathies caused by mutations in COL4A3/A4/A5 genes. These nephropathies invariably present with microscopic hematuria and frequently progress to proteinuria and CKD or ESRD during long-term follow-up. Nonetheless, the exact molecular mechanisms by which these mutations exert their deleterious effects on the...

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PMID: 24262798
DOI: 10.1681/asn.2012121217

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