Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Renal effects of cullin 3 mutations causing familial hyperkalemic hypertension.

Current opinion in nephrology and hypertension - 1 Jul 2023

Cornelius Ryan J, Maeoka Yujiro, McCormick James A

Abstract excerpt

PURPOSE OF REVIEW: Mutations in the E3 ubiquitin ligase scaffold cullin 3 (CUL3) cause the disease familial hyperkalemic hypertension (FHHt) by hyperactivating the NaCl cotransporter (NCC). The effects of these mutations are complex and still being unraveled. This review discusses recent findings revealing the molecular mechanisms underlying the effects of CUL3 mutations in the kidney. RECENT FINDINGS: The...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to Cullin Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypertension

Share to Kidney

Share to Mutation

Share to Protein Serine-Threonine Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 37070483
DOI: 10.1097/MNH.0000000000000891
PMCID: PMC10330058

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Renal effects of cullin 3 mutations causing familial hyperkalemic hypertension.PMID 37070483Read ↗

Hypertension-causing cullin 3 mutations disrupt COP9 signalosome binding.Semantic proximity Read ↗

Mutant Cullin 3 causes familial hyperkalemic hypertension via dominant effects.Semantic proximity Read ↗

Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities.Semantic proximity Read ↗

Dual gain and loss of cullin 3 function mediates familial hyperkalemic hypertension.Semantic proximity Read ↗

Characterisation of the Cullin-3 mutation that causes a severe form of familial hypertension and hyperkalaemia.Semantic proximity Read ↗

Mechanisms and controversies in mutant Cul3-mediated familial hyperkalemic hypertension.Semantic proximity Read ↗

Regulation of blood pressure and renal electrolyte balance by Cullin-RING ligases.Semantic proximity Read ↗

Distal convoluted tubule-specific disruption of the COP9 signalosome but not its regulatory target cullin 3 causes tubular injury.Semantic proximity Read ↗

Familial Hyperkalemic Hypertension.Semantic proximity Read ↗

Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and CyclingSemantic proximity Read ↗

KLHL3 mutations cause familial hyperkalemic hypertension by impairing ion transport in the distal nephron.Semantic proximity Read ↗

Mutation affecting the conserved acidic WNK1 motif causes inherited hyperkalemic hyperchloremic acidosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.