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Article

Tauroursodeoxycholic acid ameliorates renal injury induced by COL4A3 mutation.

Kidney international - 1 Sept 2024

Yu Shuwen, Gu Xiangchen, Zheng Qimin, Liu Yunzi, Suhas Teija, Du Wen, Xie Lin, Fang Zhengying, Zhao Yafei, Yang Mingxin, Xu Jing, Wang Yimei, Lin Meei-Hua, Pan Xiaoxia, Miner Jeffrey H, Jin Yuanmeng, Xie Jingyuan

Abstract excerpt

COL4A3/A4/A5 mutations have been identified as critical causes of Alport syndrome and other genetic chronic kidney diseases. However, the underlying pathogenesis remains unclear, and specific treatments are lacking. Here, we constructed a transgenic Alport syndrome mouse model by generating a mutation (Col4a3 p.G799R) identified previously from one large Alport syndrome family into mice. We observed that the...

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Source

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Identifiers

PMID: 38782199
DOI: 10.1016/j.kint.2024.04.015
PMCID: PMC11343663

Genes

COL4A3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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