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Article

Structure-function relationships of the soluble form of the antiaging protein Klotho have therapeutic implications for managing kidney disease

1 Feb 2020

Abstract excerpt

The fortuitously discovered antiaging membrane protein αKlotho (Klotho) is highly expressed in the kidney, and deletion of the Klotho gene in mice causes a phenotype strikingly similar to that of chronic kidney disease (CKD). Klotho functions as a co-receptor for fibroblast growth factor 23 (FGF23) signaling, whereas its shed extracellular domain, soluble Klotho (sKlotho), carrying glycosidase activity, is a...

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PMID: 32005658
DOI: 10.1074/jbc.ra119.012144

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