Article
Exploring the focal role of LRRK2 kinase in Parkinson's disease.
Environmental science and pollution research international - 1 May 2022
Kumar Sachin, Behl Tapan, Sehgal Aayush, Chigurupati Sridevi, Singh Sukhbir, Mani Vasudevan, Aldubayan Maha, Alhowail Ahmed, Kaur Satvinder, Bhatia Saurabh, Al-Harrasi Ahmed, Subramaniyan Vetriselvan, Fuloria Shivkanya, Fuloria Neeraj Kumar, Sekar Mahendran, Abdel Daim Mohamed M
Abstract excerpt
The major breakthroughs in our knowledge of how biology plays a role in Parkinson's disease (PD) have opened up fresh avenues designed to know the pathogenesis of disease and identify possible therapeutic targets. Mitochondrial abnormal functioning is a key cellular feature in the pathogenesis of PD. An enzyme, leucine-rich repeat kinase 2 (LRRK2), involved in both the idiopathic and familial PD risk, is a...
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