Article
Whole-genome sequencing in diverse subjects identifies genetic correlates of leukocyte traits: The NHLBI TOPMed program.
American journal of human genetics - 7 Oct 2021
Mikhaylova Anna V, McHugh Caitlin P, Polfus Linda M, Raffield Laura M, Boorgula Meher Preethi, Blackwell Thomas W, Brody Jennifer A, Broome Jai, Chami Nathalie, Chen Ming-Huei, Conomos Matthew P, Cox Corey, Curran Joanne E, Daya Michelle, Ekunwe Lynette, Glahn David C, Heard-Costa Nancy, Highland Heather M, Hobbs Brian D, Ilboudo Yann, Jain Deepti, Lange Leslie A, Miller-Fleming Tyne W, Min Nancy, Moon Jee-Young, Preuss Michael H, Rosen Jonathon, Ryan Kathleen, Smith Albert V, Sun Quan, Surendran Praveen, de Vries Paul S, Walter Klaudia, Wang Zhe, Wheeler Marsha, Yanek Lisa R, Zhong Xue, Abecasis Goncalo R, Almasy Laura, Barnes Kathleen C, Beaty Terri H, Becker Lewis C, Blangero John, Boerwinkle Eric, Butterworth Adam S, Chavan Sameer, Cho Michael H, Choquet Hélène, Correa Adolfo, Cox Nancy, DeMeo Dawn L, Faraday Nauder, Fornage Myriam, Gerszten Robert E, Hou Lifang, Johnson Andrew D, Jorgenson Eric, Kaplan Robert, Kooperberg Charles, Kundu Kousik, Laurie Cecelia A, Lettre Guillaume, Lewis Joshua P, Li Bingshan, Li Yun, Lloyd-Jones Donald M, Loos Ruth J F, Manichaikul Ani, Meyers Deborah A, Mitchell Braxton D, Morrison Alanna C, Ngo Debby, Nickerson Deborah A, Nongmaithem Suraj, North Kari E, O'Connell Jeffrey R, Ortega Victor E, Pankratz Nathan, Perry James A, Psaty Bruce M, Rich Stephen S, Soranzo Nicole, Rotter Jerome I, Silverman Edwin K, Smith Nicholas L, Tang Hua, Tracy Russell P, Thornton Timothy A, Vasan Ramachandran S, Zein Joe, Mathias Rasika A, Reiner Alexander P, Auer Paul L
Abstract excerpt
Many common and rare variants associated with hematologic traits have been discovered through imputation on large-scale reference panels. However, the majority of genome-wide association studies (GWASs) have been conducted in Europeans, and determining causal variants has proved challenging. We performed a GWAS of total leukocyte, neutrophil, lymphocyte, monocyte, eosinophil, and basophil counts generated from...
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