Article

Epistatic SNP network analysis (ESNA): A scalable framework for genome-wide detection of higher-order genetic interactions

2026-05-13

Abstract excerpt

Although genome-wide association studies (GWASs) have been widely applied to investigate the genetic basis of common traits and diseases in human populations, the associated loci do not fully account for the estimated heritability. The missing heritability may be explained, in part, by epistasis or gene-gene interactions. Existing methods for detecting epistasis, however, are limited to pair-wise interactions and/...

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Literature Corpus work: 68a74f9e-a4e2-5030-aa54-cbb8be5844d7
DOI: 10.64898/2026.05.08.26352667

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