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Correction of age-associated defects in dendritic cell functions enables CD4 <sup>+</sup> T cells to eradicate tumors in the elderly

2022-11-09

Abstract excerpt

Defective host defenses later in life are associated with changes in immune system activity. The means to correct immune defects to ensure immunity in the elderly are undefined. In this study, we found that CD8 + T cells, which are necessary for anti-tumor immunity in young mice, are not required to eradicate the same cancers later in life. Rather, CD4 + T cells drive anti-tumor immunity in elderly mice. The gen...

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Identifiers and source

Literature Corpus work
f472aec5-d94d-58f9-bc8a-d0b3dec69a61
DOI
10.1101/2022.11.08.515695
Open publication

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Correction of age-associated defects in dendritic cell functions enables CD4 <sup>+</sup> T cells to eradicate tumors in the elderlyDOI 10.1101/2022.11.08.515695
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