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Article

Age-related divergence of circulating immune responses in patients with solid tumors treated with immune checkpoint inhibitors

21 Apr 2025

Abstract excerpt

Most new cancer diagnoses occur in patients over the age of 65. The composition and function of the immune system changes with age, but how the aged immune system affects responses to immune checkpoint inhibitor (ICI) cancer therapies remains incompletely understood. Here, using multiplex cytokine assay and high-parameter mass cytometry, we analyze prospectively collected blood samples from 104 cancer patients...

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PMID: 40258833
DOI: 10.1038/s41467-025-58512-z

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