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Article

Exploiting tumor-associated dendritic cell heterogeneity for novel cancer therapies

7 Apr 2017

Abstract excerpt

Dendritic cells (DCs) are specialized APCs present in all tissues, including tumors. They play a major role in orchestrating immune responses and were shown to occur in various functional states in tumors. In this respect, immunogenic tumor-associated DCs (TADCs) are required to initiate and sustain T cell-dependent anti-cancer immunity, whereas regulatory TADCs harbor robust immunosuppressive potential and...

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PMID: 28389620
DOI: 10.1189/jlb.4mr1116-466r

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