Article
Challenges and future directions for studying effects of host genetics on the gut microbiome.
Nature genetics - 1 Feb 2022
Sanna Serena, Kurilshikov Alexander, van der Graaf Adriaan, Fu Jingyuan, Zhernakova Alexandra
Abstract excerpt
The human gut microbiome is a complex ecosystem that is involved in its host's metabolism, immunity and health. Although interindividual variations in gut microbial composition are mainly driven by environmental factors, some gut microorganisms are heritable and thus can be influenced by host genetics. In the past 5 years, 12 microbial genome-wide association studies (mbGWAS) with >1,000 participants have been...
Topics
- ABO Blood-Group System
- Biological Variation, Population
- Fucosyltransferases
- Gastrointestinal Microbiome
- Genetic Variation
- Genome-Wide Association Study
- Genomics
- Host Microbial Interactions
- Humans
- Lactase
- Polymorphism, Single Nucleotide
- Quantitative Trait Loci
- Galactoside 2-alpha-L-fucosyltransferase