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Article

Challenges and future directions for studying effects of host genetics on the gut microbiome.

Nature genetics - 1 Feb 2022

Sanna Serena, Kurilshikov Alexander, van der Graaf Adriaan, Fu Jingyuan, Zhernakova Alexandra

Abstract excerpt

The human gut microbiome is a complex ecosystem that is involved in its host's metabolism, immunity and health. Although interindividual variations in gut microbial composition are mainly driven by environmental factors, some gut microorganisms are heritable and thus can be influenced by host genetics. In the past 5 years, 12 microbial genome-wide association studies (mbGWAS) with >1,000 participants have been...

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PMID: 35115688
DOI: 10.1038/s41588-021-00983-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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