Article
The effect of host genetics on the gut microbiome.
Nature genetics - 1 Nov 2016
Bonder Marc Jan, Kurilshikov Alexander, Tigchelaar Ettje F, Mujagic Zlatan, Imhann Floris, Vila Arnau Vich, Deelen Patrick, Vatanen Tommi, Schirmer Melanie, Smeekens Sanne P, Zhernakova Daria V, Jankipersadsing Soesma A, Jaeger Martin, Oosting Marije, Cenit Maria Carmen, Masclee Ad A M, Swertz Morris A, Li Yang, Kumar Vinod, Joosten Leo, Harmsen Hermie, Weersma Rinse K, Franke Lude, Hofker Marten H, Xavier Ramnik J, Jonkers Daisy, Netea Mihai G, Wijmenga Cisca, Fu Jingyuan, Zhernakova Alexandra
Abstract excerpt
The gut microbiome is affected by multiple factors, including genetics. In this study, we assessed the influence of host genetics on microbial species, pathways and gene ontology categories, on the basis of metagenomic sequencing in 1,514 subjects. In a genome-wide analysis, we identified associations of 9 loci with microbial taxonomies and 33 loci with microbial pathways and gene ontology terms at P < 5 × 10-8....
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