Article
Effect of host genetics on the gut microbiome in 7,738 participants of the Dutch Microbiome Project.
Nature genetics - 1 Feb 2022
Lopera-Maya Esteban A, Kurilshikov Alexander, van der Graaf Adriaan, Hu Shixian, Andreu-Sánchez Sergio, Chen Lianmin, Vila Arnau Vich, Gacesa Ranko, Sinha Trishla, Collij Valerie, Klaassen Marjiolein A Y, Bolte Laura A, Gois Milla F Brandao, Neerincx Pieter B T, Swertz Morris A, Harmsen Hermie J M, Wijmenga Cisca, Fu Jingyuan, Weersma Rinse K, Zhernakova Alexandra, Sanna Serena
Abstract excerpt
Host genetics are known to influence the gut microbiome, yet their role remains poorly understood. To robustly characterize these effects, we performed a genome-wide association study of 207 taxa and 205 pathways representing microbial composition and function in 7,738 participants of the Dutch Microbiome Project. Two robust, study-wide significant (P < 1.89 × 10-10) signals near the LCT and ABO genes were found...
Topics
- ABO Blood-Group System
- Bacterial Physiological Phenomena
- Bifidobacterium
- Diet
- Fucosyltransferases
- Gastrointestinal Microbiome
- Gastrointestinal Tract
- Genetic Variation