Article
Large-scale association analyses identify host factors influencing human gut microbiome composition.
Nature genetics - 1 Feb 2021
Kurilshikov Alexander, Medina-Gomez Carolina, Bacigalupe Rodrigo, Radjabzadeh Djawad, Wang Jun, Demirkan Ayse, Le Roy Caroline I, Raygoza Garay Juan Antonio, Finnicum Casey T, Liu Xingrong, Zhernakova Daria V, Bonder Marc Jan, Hansen Tue H, Frost Fabian, Rühlemann Malte C, Turpin Williams, Moon Jee-Young, Kim Han-Na, Lüll Kreete, Barkan Elad, Shah Shiraz A, Fornage Myriam, Szopinska-Tokov Joanna, Wallen Zachary D, Borisevich Dmitrii, Agreus Lars, Andreasson Anna, Bang Corinna, Bedrani Larbi, Bell Jordana T, Bisgaard Hans, Boehnke Michael, Boomsma Dorret I, Burk Robert D, Claringbould Annique, Croitoru Kenneth, Davies Gareth E, van Duijn Cornelia M, Duijts Liesbeth, Falony Gwen, Fu Jingyuan, van der Graaf Adriaan, Hansen Torben, Homuth Georg, Hughes David A, Ijzerman Richard G, Jackson Matthew A, Jaddoe Vincent W V, Joossens Marie, Jørgensen Torben, Keszthelyi Daniel, Knight Rob, Laakso Markku, Laudes Matthias, Launer Lenore J, Lieb Wolfgang, Lusis Aldons J, Masclee Ad A M, Moll Henriette A, Mujagic Zlatan, Qibin Qi, Rothschild Daphna, Shin Hocheol, Sørensen Søren J, Steves Claire J, Thorsen Jonathan, Timpson Nicholas J, Tito Raul Y, Vieira-Silva Sara, Völker Uwe, Völzke Henry, Võsa Urmo, Wade Kaitlin H, Walter Susanna, Watanabe Kyoko, Weiss Stefan, Weiss Frank U, Weissbrod Omer, Westra Harm-Jan, Willemsen Gonneke, Payami Haydeh, Jonkers Daisy M A E, Arias Vasquez Alejandro, de Geus Eco J C, Meyer Katie A, Stokholm Jakob, Segal Eran, Org Elin, Wijmenga Cisca, Kim Hyung-Lae, Kaplan Robert C, Spector Tim D, Uitterlinden Andre G, Rivadeneira Fernando, Franke Andre, Lerch Markus M, Franke Lude, Sanna Serena, D'Amato Mauro, Pedersen Oluf, Paterson Andrew D, Kraaij Robert, Raes Jeroen, Zhernakova Alexandra
Abstract excerpt
To study the effect of host genetics on gut microbiome composition, the MiBioGen consortium curated and analyzed genome-wide genotypes and 16S fecal microbiome data from 18,340 individuals (24 cohorts). Microbial composition showed high variability across cohorts: only 9 of 410 genera were detected in more than 95% of samples. A genome-wide association study of host genetic variation regarding microbial taxa...
