Article
Environment dominates over host genetics in shaping human gut microbiota.
Nature - 8 Mar 2018
Rothschild Daphna, Weissbrod Omer, Barkan Elad, Kurilshikov Alexander, Korem Tal, Zeevi David, Costea Paul I, Godneva Anastasia, Kalka Iris N, Bar Noam, Shilo Smadar, Lador Dar, Vila Arnau Vich, Zmora Niv, Pevsner-Fischer Meirav, Israeli David, Kosower Noa, Malka Gal, Wolf Bat Chen, Avnit-Sagi Tali, Lotan-Pompan Maya, Weinberger Adina, Halpern Zamir, Carmi Shai, Fu Jingyuan, Wijmenga Cisca, Zhernakova Alexandra, Elinav Eran, Segal Eran
Abstract excerpt
Human gut microbiome composition is shaped by multiple factors but the relative contribution of host genetics remains elusive. Here we examine genotype and microbiome data from 1,046 healthy individuals with several distinct ancestral origins who share a relatively common environment, and demonstrate that the gut microbiome is not significantly associated with genetic ancestry, and that host genetics have a minor...
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