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Article

Host genetic variation impacts microbiome composition across human body sites.

Genome biology - 15 Sept 2015

Blekhman Ran, Goodrich Julia K, Huang Katherine, Sun Qi, Bukowski Robert, Bell Jordana T, Spector Timothy D, Keinan Alon, Ley Ruth E, Gevers Dirk, Clark Andrew G

Abstract excerpt

BACKGROUND: The composition of bacteria in and on the human body varies widely across human individuals, and has been associated with multiple health conditions. While microbial communities are influenced by environmental factors, some degree of genetic influence of the host on the microbiome is also expected. This study is part of an expanding effort to comprehensively profile the interactions between human...

Topics

Bacteria
Genetic Variation
Genome, Human
Humans
Metagenomics
Microbiota

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 26374288
DOI: 10.1186/s13059-015-0759-1
PMCID: PMC4570153

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