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Article

Microbiome-associated human genetic variants impact phenome-wide disease risk.

Proceedings of the National Academy of Sciences of the United States of America - 28 Jun 2022

Markowitz Robert H George, LaBella Abigail Leavitt, Shi Mingjian, Rokas Antonis, Capra John A, Ferguson Jane F, Mosley Jonathan D, Bordenstein Seth R

Abstract excerpt

Human genetic variation associates with the composition of the gut microbiome, yet its influence on clinical traits remains largely unknown. We analyzed the consequences of nearly a thousand gut microbiome-associated variants (MAVs) on phenotypes reported in electronic health records from tens of thousands of individuals. We discovered and replicated associations of MAVs with neurological, metabolic, digestive,...

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Identifiers

PMID: 35749358
DOI: 10.1073/pnas.2200551119
PMCID: PMC9245617

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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