Article
APOE, MAPT, and SNCA genes and cognitive performance in Parkinson disease.
JAMA neurology - 1 Nov 2014
Mata Ignacio F, Leverenz James B, Weintraub Daniel, Trojanowski John Q, Hurtig Howard I, Van Deerlin Vivianna M, Ritz Beate, Rausch Rebecca, Rhodes Shannon L, Factor Stewart A, Wood-Siverio Cathy, Quinn Joseph F, Chung Kathryn A, Peterson Amie L, Espay Alberto J, Revilla Fredy J, Devoto Johnna, Hu Shu-Ching, Cholerton Brenna A, Wan Jia Y, Montine Thomas J, Edwards Karen L, Zabetian Cyrus P
Abstract excerpt
IMPORTANCE: Cognitive impairment is a common and disabling problem in Parkinson disease (PD) that is not well understood and is difficult to treat. Identification of genetic variants that influence the rate of cognitive decline or pattern of early cognitive deficits in PD might provide a clearer understanding of the etiopathogenesis of this important nonmotor feature. OBJECTIVE: To determine whether common...
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