Association of GBA Mutations and the E326K Polymorphism With Motor and Cognitive Progression in Parkinson Disease.

doi:10.1001/jamaneurol.2016.2245

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Association of GBA Mutations and the E326K Polymorphism With Motor and Cognitive Progression in Parkinson Disease.

JAMA neurology - 1 Oct 2016

Davis Marie Y, Johnson Catherine O, Leverenz James B, Weintraub Daniel, Trojanowski John Q, Chen-Plotkin Alice, Van Deerlin Vivianna M, Quinn Joseph F, Chung Kathryn A, Peterson-Hiller Amie L, Rosenthal Liana S, Dawson Ted M, Albert Marilyn S, Goldman Jennifer G, Stebbins Glenn T, Bernard Bryan, Wszolek Zbigniew K, Ross Owen A, Dickson Dennis W, Eidelberg David, Mattis Paul J, Niethammer Martin, Yearout Dora, Hu Shu-Ching, Cholerton Brenna A, Smith Megan, Mata Ignacio F, Montine Thomas J, Edwards Karen L, Zabetian Cyrus P

Abstract excerpt

IMPORTANCE: Parkinson disease (PD) is heterogeneous in symptom manifestation and rate of progression. Identifying factors that influence disease progression could provide mechanistic insight, improve prognostic accuracy, and elucidate novel therapeutic targets. OBJECTIVE: To determine whether GBA mutations and the E326K polymorphism modify PD symptom progression. DESIGN, SETTING, AND PARTICIPANTS: The entire GBA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cognitive Dysfunction

Share to Dementia

Share to Disease Progression

Share to Glucosylceramidase

Share to Longitudinal Studies

Share to Parkinson Disease

Share to Polymorphism, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 27571329
DOI: 10.1001/jamaneurol.2016.2245
PMCID: PMC5056861

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of GBA Mutations and the E326K Polymorphism With Motor and Cognitive Progression in Parkinson Disease.PMID 27571329Read ↗

Genetic risk of Parkinson disease and progression:Semantic proximity Read ↗

Association of Dual LRRK2 G2019S and GBA Variations With Parkinson Disease Progression.Semantic proximity Read ↗

Association of GBA Genotype With Motor and Functional Decline in Patients With Newly Diagnosed Parkinson Disease.Semantic proximity Read ↗

Genome-wide association study of Parkinson’s disease progression biomarkers in 12 longitudinal patients’ cohortsSemantic proximity Read ↗

GBA Variants are associated with a distinct pattern of cognitive deficits in Parkinson's disease.Semantic proximity Read ↗

Association of GBA genotype with motor and cognitive decline in Chinese Parkinson’s disease patientsSemantic proximity Read ↗

Genomewide association study of Parkinson's disease clinical biomarkers in 12 longitudinal patients' cohortsSemantic proximity Read ↗

Features of GBA-associated Parkinson's disease at presentation in the UK Tracking Parkinson's study.Semantic proximity Read ↗

Faster disease progression in Parkinson's disease with glucocerebrosidase genotype: But not apparent immediate from diagnosis.Semantic proximity Read ↗

GBA-associated PD: chances and obstacles for targeted treatment strategies.Semantic proximity Read ↗

The GBA variant E326K is associated with Parkinson's disease and explains a genome-wide association signal.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.